Alignment of C. elegans ADM-2 with human ADAMs.
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posted on 2022-05-31, 17:35 authored by Braveen B. Joseph, Phillip T. Edeen, Sarina Meadows, Shaonil Binti, David S. FayPeptide alignment of C. elegans ADM-2 with human meltrin family members (ADAM9/12/19/33). Predicted domains of ADM-2 are color coded. NLS, nuclear localization domain.
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widespread developmental processmany genes requireddiv >< ptwo conserved membersseveral mammalian adamsexternal extracellular matrixintracellular trafficking regulatorsendocytic trafficking may2 overexpression causedadam family memberepidermally expressed lowapical epidermal lrp>, including mutations1 strongly affectedcaenorhabditis elegans 2 activity ledfamily metalloprotease admconserved adamelegans nek familymatrix metalloproteasesmammalian homologs2 metalloprotease domainc turn drivestrong suppressionproteolytic processingprotein kinasesorganismal growthmodifying enzymesmeltrin adam12lysosomal networklike receptorlead ushormone precursorsfindings suggestenvironmental steroidenvironmental adaptationdiverse setcyclic inductioncandidate target1 levels
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