lin-15B is a negative regulator of pals-5p::GFP expression.

(A, B) Mutants isolated from two independent forward genetic screens in pals-22 pals-25 double mutant (A) and wild-type backgrounds (B) show increased expression of pals-5p::GFP reporter (shown in green). myo-2p::mCherry co-injection marker is shown in magenta. Green, magenta and DIC channels were merged. Scale bar = 200 µm. (C) lin-15B gene structure. lin-15B exons are indicated with green boxes, UTRs are shown in light gray, region encoding THAP domain is indicated with striped magenta box. Horizontal arrow shows the direction of transcription. Vertical arrows indicate positions of point mutations in alleles jy76 and jy86.