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Rrp40G11A mutant flies show defects in mushroom body morphology.

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posted on 2020-07-09, 17:55 authored by Derrick J. Morton, Binta Jalloh, Lily Kim, Isaac Kremsky, Rishi J. Nair, Khuong B. Nguyen, J. Christopher Rounds, Maria C. Sterrett, Brianna Brown, Thalia Le, Maya C. Karkare, Kathryn D. McGaughey, Shaoyi Sheng, Sara W. Leung, Milo B. Fasken, Kenneth H. Moberg, Anita H. Corbett

Three representative images of merged projections of FasII-stained mushroom bodies from Rrp40-WT control flies (n = 18) (top row), Rrp40G11A (G11A/G11A) mutant flies (n = 23) (middle row), and Rrp40D87A (D87A/D87A) mutant flies (n = 18) (bottom row) are shown. In control flies, β-lobes do not cross the mid-line and well-formed α and β-lobes are readily apparent. In Rrp40G11A mutant flies, 13/23 (57%) brains examined showed defects in β-lobe structure or β-lobe fusion (white arrows). Neither β-lobe defect was detected in the Rrp40D87A mutant flies.

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