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In vivo near-infrared fluorescence imaging of Xenolight 750 probes in the rat AVM model.

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posted on 2017-09-26, 17:36 authored by Newsha Raoufi-Rad, Lucinda S. McRobb, Vivienne S. Lee, David Bervini, Michael Grace, Jaysree Ukath, Joshua Mchattan, Varun K. A. Sreenivasan, T. T. Hong Duong, Zhenjun Zhao, Marcus A. Stoodley

Rats with an AVM creation were sham treated or irradiated with a 15 Gy marginal dose to the AVM region by Gamma Knife and imaging performed 12 h after conjugate dye injection (25 μg/kg). Representative montages of x-ray (left), fluorescent (centre) and merged (right) images after injection of Xenolight 750 probes: (A) Xenolight-750 isotype control in irradiated animal; (B) Xenolight 750-ICAM-1 probe and; (C) Xenolight 750-VCAM-1 probe, at day 21 after sham (top panels) or radiation (bottom panels). Image J quantitation of fluorescence at day 21 post-irradiation or sham with Xenolight 750-ICAM-1 (D) or Xenolight 750-VCAM-1 (E) probes and Xenolight-750 isotype control probe.

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