Fig 11.tif (547.77 kB)
In silico analysis of links between array peptides with significantly altered phosphorylation levels and pro-inflammatory cytokines induced by N. meningitidis.
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posted on 2018-01-19, 21:09 authored by Unni Gopinathan, Kathrine Røe Redalen, Anne-Marie Trøseid, Peter Kierulf, Petter Brandtzaeg, Anne Hansen Ree, Jens Petter Berg, Reidun ØvstebøDisplay of presently known links between array peptides with phosphorylation levels significantly altered by lysates from human monocytes stimulated with N. meningitidis, and pro-inflammatory cytokines. The pathway analysis tools “Build” and “Connect” were used to identify the links, and connections were filtered to only include direct links between molecules identified in immune cells from human, rat, mice or immune cell line models. In silico analysis identified links pointing from ZBTB16 towards TNF, IL-6, and CXCL10.
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cell functionsVEGFmonocyte model systemstudy changessignal transduction10 6 NPTENLarge-scale reductiontyrosine kinase activitiesgene expression changesIngenuity Pathway Analysiskinase activitycell lysatesNf -κBmeningococcal sepsistyrosine kinase-mediated signal transductionmRNA levelsIL -10 anti-inflammatory responsevivo array peptide phosphorylationmRNA datatumor necrosis factorarray peptide phosphorylationanti-inflammatory cytokine interleukin -10meningitidis Ncytokine release144 kinase peptide substratesCXCL 10.15 minutesTNFZBTB60 minutesSTAT 3 activitykinase activitieskinase substrate arrays
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