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IKACh relaxation is induced by ACh-M2R.

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posted on 14.01.2022, 21:04 by Ana Laura López-Serrano, Rodrigo Zamora-Cárdenas, Iván A. Aréchiga-Figueroa, Pedro D. Salazar-Fajardo, Tania Ferrer, Javier Alamilla, José A. Sánchez-Chapula, Ricardo A. Navarro-Polanco, Eloy G. Moreno-Galindo

a) Typical steady-state IKACh traces obtained in the presence of 0.3 (A) and 10 μM ACh (b) with a voltage protocol (inset). For clarity, current traces evoked at voltages -110, -90, -70, -30, +10, and +50 mV are only depicted. c) Fraction of open channels (Iins/Imax) as a function of the pre-pulse potential for the currents evoked by 0.3 and 10 μM ACh. n = 5 for each ACh concentration.