dunce¹ temporal rescue.

A. Injection of Mifepristone (M) in pupae (see Methods) to activate dunce expression throughout mutant dnc¹ brains rescued (*, P<0.05, by Wilcoxon rank sum) the selective novelty response across two frequency domains. N = 5 flies. B. Injection of only the vehicle (DMSO, see Methods) in pupae of the same strain as in A did not produce any significant novelty responses in adult flies. N = 5 flies. Baseline responses immediately preceding novelty are shown in Figure S6.