(a–f). Fold changes in expression of IL10, IFNγ and IFNβ genes in tissues of mice after RVFV infection.

RecNP immunized mice (n = 3 per time point) are indicated by solid black bars, adjuvant control mice (n = 3 per time point) by grey bars and PBS control mice (n = 3 per time point) by white bars. The horizontal dotted lines indicate the cut-off values for upregulation (+2) or downregulation (−2). The asterisk (*) indicates where the P-value is smaller than or equal to 0.05 (statistically significant results). Standard error values are indicated by the error bars. Note the differences in the Y-axis scales. The following time points are indicated: 3, 6, 12, 24, 72 and 120 hours.