posted on 2013-01-31, 02:02authored byLan Guo, Heng Du, Shiqiang Yan, Xiaoping Wu, Guy M. McKhann, John Xi Chen, Shirley ShiDu Yan
Aβ-Cyclphilin D mediates impairments in axonal mitochondrial transport. In the present of Aβ, there is an increase in the opening of CypD-mediated mitochondrial permeability transition pore (mPTP), leading to disruption of Ca2+ balance and increase in reactive oxygen species (ROS) production/accumulation. Consequently, elevation of Ca2+ and oxidative activates downstream signal pathway p38 MAP Kinase contributing to mitochondrial dysfunction, deficits in axonal mitochondrial trafficking, eventually, synaptic damage.