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Virus Titres in Throat- and Nasal Swabs in control and vaccinated ferrets post challenge.

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posted on 2014-05-21, 03:04 authored by Alex J. Mann, Nicolas Noulin, Andrew Catchpole, Koert J. Stittelaar, Leon de Waal, Edwin J. B. Veldhuis Kroeze, Michael Hinchcliffe, Alan Smith, Emanuele Montomoli, Simona Piccirella, Albert D. M. E. Osterhaus, Alastair Knight, John S. Oxford, Giulia Lapini, Rebecca Cox, Rob Lambkin-Williams

Both throat swabs (3A) and nasal swabs (3B) were analysed for viral loads by cell culture (log10TCID50/mL) and plotted daily after challenge. Plots contain mean daily mean titres with ± SD for each treatment. The following treatment groups were challenged with HPAI virus by the intratracheal route: red circle = placebo group challenged, green squares = unadjuvanted/antigen alone vaccine group, blue triangles = CSN adjuvanted vaccine, orange diamonds = TM-CSN adjuvanted vaccine. The following groups were challenge by the intranasal route: black diamonds = placebo, and blue circles = CSN adjuvanted vaccine.