Urinary albumin excretion (UAE) in male Akita mice.
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posted on 2013-02-20, 06:53 authored by Jae-Hyung Chang, Seung-Yeol Paik, Lan Mao, William Eisner, Patrick J. Flannery, Liming Wang, Yuping Tang, Natalie Mattocks, Samy Hadjadj, Jean-Michel Goujon, Phillip Ruiz, Susan B. Gurley, Robert F. Spurney(A) UAE was significantly elevated compared with controls in diabetic Akita mice by 8 weeks of age. By 20 weeks of age, there was a >10-fold increase in albuminuria in diabetic mice compared to control animals. (B) Albumin-to-creatinine ratio (ACR) was also significantly increased in diabetic mice compared to age-matched controls. (C) There was a linear relationship between 24-hour UAE and ACR in all mice (R2 = 0.71; P<0.0001). Black bars = control (n = 6 to 8); white bars = Akita (n = 6 to 8). Black circles = control; white circles = Akita. Data are mean ± SEM. *P<0.05 or †P<0.0001 vs. age-matched controls.
