Tumor cell proliferation and apoptosis in Casp6 overexpressing and deficient mice.

(A) Representative Ki67 immunohistochemistry in tumors in WT/WT, WT/Cre, KI/WT and KI/Cre mice given AOM/DSS (scale bar, 100 µm). (B) Number of Ki67 positive cells in colonic tumors from mice (N = 3). Data expressed as means +/− SEM. (C) Representative Ki67 immunohistochemistry in tumors from WT/WT, WT/KO, and KO/KO mice given AOM/DSS (scale bar, 100 µm). (D) Number of Ki67 positive cells in colonic tumors from KO mice (N = 3). Data expressed as means +/− SEM. (E) Representative Cleaved Casp3 immunohistochemistry in positive control (fetal ischemic brain), negative control (colon without Primary Antibody) and a colon from AOM/DSS treated mouse (scale bar, 50 µm). Number of cleaved Casp3 positive cells in colonic tumors from mice (N = 3). Data expressed as means +/− SEM. (F) Number of Cleaved Casp3 positive cells in colonic tumors from KO mice (N = 3). Data expressed as means +/− SEM.