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Trehalose induced podocyte autophagy in an mTOR independent manner.
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posted on 2014-11-20, 03:26 authored by Yu-Lin Kang, Moin Ahson Saleem, Kwok Wah Chan, Benjamin Yat-Ming Yung, Helen Ka-Wai LawmTOR activity was not altered in trehalose-treated podocytes. Podocytes were treated with trehalose (50 mM) for 0, 12, 24, 36, 48 and 60 h. The phosphorylation level of p-mTOR (A) and its substrates p-p70S6K (B) and p-4E-BP1 (C) were measured by Western blotting, n = 5, 5 and 6 respectively. However, no significant changes were observed. The representative immunoblot was shown along with the statistical results.
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Alleviates Human Podocyte InjuryPuromycin Aminonucleoside Treatment Glomerular diseasesreactive oxygen species involvementattenuate podocyte injuryLactate dehydrogenase activityautophagymTOR Independent Autophagy InducerPodocyte apoptosischange nephrotic syndromepodocyte injurytrehaloseactin cytoskeleton rearrangementLC 3 puncta
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