Figure_7.tif (10.45 MB)
Trehalose diminished cell motility in PAN-treated human podocytes.
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posted on 2014-11-20, 03:26 authored by Yu-Lin Kang, Moin Ahson Saleem, Kwok Wah Chan, Benjamin Yat-Ming Yung, Helen Ka-Wai LawPodocyte were treated with PAN (30 µg/ml) or/and Trehalose (50 mM) for 12 h. (A) PAN-increased podocyte motility was suppressed by trehalose. The representative images were taken under inverted microscope (50×). (B) The number of cells migrating into the gap was calculated for evaluating podocyte motility. The migrated podocytes after PAN treatment increased significantly, whereas trehalose suppressed this enhanced motility. **p<0.01, ***p<0.001 versus CON, n = 6.
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Alleviates Human Podocyte InjuryPuromycin Aminonucleoside Treatment Glomerular diseasesreactive oxygen species involvementattenuate podocyte injuryLactate dehydrogenase activityautophagymTOR Independent Autophagy InducerPodocyte apoptosischange nephrotic syndromepodocyte injurytrehaloseactin cytoskeleton rearrangementLC 3 puncta
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