Time course of serum insulin level and glucose metabolism situation of mice.

Figure 2A showed that db/db obese mice had higher level of insulin at each time point than lean control. * p<0.05 **p<0.01 vs lean control at same age. Compared with the lean group, db/db obese mice had normal response to intraperitoneal glucose tolerance test(ipGTT) at the age of 5w, had impaired ipGTT at the age of 6w and increased fasting glucose level at the age of 10w (Fig. 2B).