The interface of the S100P-RAGE V domain complex.

(a) Electrostatic surface representation of the binding interface of the RAGE V domain in complex with S100P (gray ribbon), with the S100P residues involved in the interaction represented as sticks. (b) Electrostatic surface representation of S100P in complex with the RAGE V domain (gray ribbon), with the residues in the RAGE V domain that are involved in the interaction represented as sticks. Positively charged, negatively charged, and neutral regions are represented in blue, red and white, respectively. The atoms in S100P and the RAGE V domain are colored gray (carbon), red (oxygen) and blue (nitrogen).