The fungal metabolic network of interactions between gene clustering and two major sources of gene innovation (GD and HGT).

Nodes of the metabolic network correspond to KEGG compounds. Thick edges of the metabolic network correspond to EC numbers from clustered ECgenes in one or more fungal species, whereas thin edges to EC numbers whose genes show no history of gene clustering. Colored edges correspond to EC numbers whose ECgenes have undergone HGT and GD (red), GD (blue), or show no history of GD or HGT (black). Note that none of the EC numbers in our dataset were affected by HGT alone. Pathway map created using iPATH2.0 [95].