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TRAMPfmsmic-1 mice survive longer and have smaller prostate tumors than TRAMP mice.

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posted on 2013-02-20, 00:20 authored by Yasmin Husaini, Min Ru Qiu, Glen P. Lockwood, Xu Wei Luo, Ping Shang, Tamara Kuffner, Vicky Wang-Wei Tsai, Lele Jiang, Pamela J. Russell, David A. Brown, Samuel N. Breit

Overall survival of individual mice from birth to death is shown (panel A). The survival data for TRAMP (—▴—) and TRAMPfmsmic-1 (—Δ—) mice were plotted using the Kaplan-Meier method. The log-rank statistic for median survival time is shown. The genitourinary (GU), seminal vesicle (SV) and prostate tumor sizes in TRAMPfmsmic-1 and TRAMP mice (n = 15/group) sacrificed at 8, 17, 25 and 33 weeks of age are shown in panel B, C and D. The GU (panel B), SV (panel C) and prostate weights (panel D) are presented as mean mg weight/g body weight ± SEM. p values are shown as *p<0.05; **p<0.01; ***p<0.001.

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