Figure_6.tif (125.26 kB)
TLR4 deficiency reduced macrophage accumulation in diabetic nephropathy.
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posted on 2014-05-19, 03:23 authored by Jin Ma, Steven J. Chadban, Cathy Y. Zhao, Xiaochen Chen, Tony Kwan, Usha Panchapakesan, Carol A. Pollock, Huiling WuMacrophage (CD68+ or F8/40+) accumulation was evident in WT mice with diabetes, but prevented by TLR4 deficiency in both the interstitial (A) and glomerular (B & C) compartments. Data are present as means ± SEM; * p<0.05; *** p<0.001.
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cell biologySignal transductioncell signalingMembrane receptor signalingImmune receptor signalingImmunological signalingMolecular cell biologyMetabolic disordersDiabetes mellitusType 1 diabetestype 2 diabetesNephrologyChronic kidney diseaseModel organismsAnimal modelsMouse modelsdeficiencyreducedmacrophageaccumulationdiabetic
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