Synthesis of the fucose/mannose hybrid 4 and its derivative deoxyhybrid 6.
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posted on 2014-11-21, 02:58 authored by Roman Sommer, Thomas E. Exner, Alexander TitzReagents and conditions: (a) Compound 16 was synthesized as reported [20]; (b) Pt/C, H2, HCl, MeOH, r.t., 2 d; (c) NaNO2, AcOH, H2O, r.t., 1 d; (d) NaOMe/MeOH, r.t., 30 min, AcCl/EtSH, 0°C, 1.5 h, r.t., 1 h; (e) Raney Nickel, EtOH, 78°C, 30 min; (f) various conditions following the protocol of Bihovsky et al. [41].
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hydroxymethyl groupmethyl groupBiophysical Studybiofilm formationfuture drug designCarbohydrate DerivativesMolecular BasisMonosaccharide Selectivitycarbohydrate ligandsPseudomonas aeruginosa Lectin LecBcrystal structurelectin LecBPseudomonas aeruginosareport glycomimetic inhibitorsmannose derivativeshydrogen bondsaccharide precursorsambient conditions
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