Structure of coelacanth endogenous retrovirus CoeERV1-1.

(A) Solo-LTR observed in L. chalumnae. (B) Schematic representation of ERV insertion 23 found at the orthologous position in L. menadoensis. (C) Reconstructed structure of CoeERV1-1 in the L. chalumnae genome. TSD  =  Target Site Duplication; LTR  =  Long Terminal Repeats; Gag: ORF encoding protein for the viral capsid; Pol: ORF encoding proteins responsible for synthesis of the viral DNA and integration into host DNA, including protease (Pro), reverse transcriptase (RT), ribonuclease H (RH) and integrase (Int); Env: ORF encoding envelope protein.