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Structure-activity relationship of SRPIN340/nicotinoyl derivatives to the replication of the HCV subreplicon.

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posted on 2011-08-17, 01:41 authored by Azlinda Anwar, Takamitsu Hosoya, Kok Mun Leong, Hiroshi Onogi, Yukiko Okuno, Toshiyuki Hiramatsu, Hiroko Koyama, Masaaki Suzuki, Masatoshi Hagiwara, Mariano A. Garcia-Blanco

The comparison of the relative luciferase activity (luc activity) and viability (viability) with the solvent (0.04% DMSO) in the presence of 10 or 20 µM of the compounds are shown. L/V is the ratio of relative luciferase activity to viability. L/V values less than 50 (20 µM) or 60 (10 µM) are highlighted. The data are represented as the mean of triplicate experiments.

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