Structure-activity relationship of SRPIN340/nicotinoyl derivatives to the replication of the HCV subreplicon.

The comparison of the relative luciferase activity (luc activity) and viability (viability) with the solvent (0.04% DMSO) in the presence of 10 or 20 µM of the compounds are shown. L/V is the ratio of relative luciferase activity to viability. L/V values less than 50 (20 µM) or 60 (10 µM) are highlighted. The data are represented as the mean of triplicate experiments.