Smaller significant network modules: network diagrams.

Network edges displayed in green and red indicate positive and negative hazard ratios, respectively, for the DNAm network correlation measure corresponding to that interaction; these correspond, respectively, to an increase and decrease in ‘network interaction co-ordinatedness’ for worse disease prognosis. (a) Wound healing module (KIRC). (b) Immune module (UCEC). (c) Mitochondial module (LUAD). (d) MAP-kinase module (LUSC). (e) Largest biologically significant subnetwork in the BLCA data set. (f) Largest biologically significant subnetwork in the BRCA data set. Further details about the corresponding network nodes (genes) and significantly enriched gene sets appear in tables 6–9 and S1–4.