Simvastatin decreased infact area of MCAO rats. A:

representative photographs of brain slices; no infarct area detected in sham group. B: the fourth brain slice of each rat picked out for statistical analysis; MCAO and vehicle+MCAO group showing a significant lesion, but sim+MCAO group indicating improvement in infarct area; values expressed as means ± SEM of 6 rats; ##P<0.01, sim+MCAO vs. MCAO group; &&P<0.01, sim+MCAO vs. vehicle+MCAO group. Sim, Simvastatin.