Simulated model behavior in abnormal physiological conditions obtained by varying some parameters.
Panel A reports the Time course of model-simulated arterial pressure (mmHg), on the left, and the model-simulated cerebral blood flow velocity (CBFV, mL/sec), on the right, varying the parameter kxf. The continuous line describes the trend in the physiological situation (kxf = 0.5), the dashed black line describes the trend with kxf = 0.7 whereas the dashed gray line describes the trend with kxf = 0.3. Panel B reports the time course of model-simulated arterial pressure (mmHg), on the left, and model-simulated cerebral blood flow velocity (CBFV, mL/sec), on the right, varying the parameter kh. The continuous line describes the trend in the physiological situations (kh = 0.05), the dashed black line describes the trend with kh = 0.07 and the dashed gray line describes the trend with kh = 0.02. Panel C reports the time course of model-simulated arterial pressure (mmHg), on the left, and model-simulated cerebral blood flow velocity (CBFV, mL/sec), on the right, varying the parameter kxca. The continuous line describes the trend in the physiological situations (kxca = 0.01), the dashed black line describes the trend with kxca = 0.06 whereas the dashed gray line describes the trend for kxca = 0.005.