Shared antigen-specific clonotype protein sequences are simpler to generate and more abundant than those that are not shared between individuals.

A) Plot of the relative abundance of each shared (identified in more than one individual) and not shared Flu M1- and EBV BMLF1-specific clonotype protein sequence identified by MIRA in a library of 10⁹ simulated sequences generated by VDJ recombination. The relative complexity of each clonotype was measured as the abundance of each sequence in the library of 10⁹ simulated clonotypes with more abundant clonotypes being easier to generate than those that are less abundant. B) Plot of the frequencies of each shared (identified in more than one individual) and not shared Flu M1- and EBV BMLF1-specific clonotype nucleotide sequence identified by MIRA. Blue lines indicate the median observations (A) and frequencies (B) for each group.