Schematic representation of Lrp4 in tooth development.
figure
posted on 2008-12-31, 01:02 authored by Atsushi Ohazama, Eric B. Johnson, Masato S. Ota, Hong J. Choi, Thantrira Porntaveetus, Shelly Oommen, Nobuyuki Itoh, Kazuhiro Eto, Amel Gritli-Linde, Joachim Herz, Paul T. SharpeSignalling of Lrp4 and Wise regulating tooth development. BMPs bind to the Ectodin/Wise, which in turn binds to Lrp4 inhibiting Wnt signalling. In the absence of Lrp4 or Wise, the excess BMPs bind to their receptor and activate both Wnt and Bmp signalling, which can result in downregulation of signalling.
