Schematic representation of HIV-1 gp41 and rsgp41.

(A) Functional domains of the HIV-1 gp41. FP, fusion peptide; NHR, N-terminal heptad repeat; CHR, C-terminal heptad repeat; TM, transmembrane domain; CP, cytoplasmic domain. (B) Schematic representation of rsgp41. The dashed lines between the gp41 NHR and CHR domain indicate the interactions between the residues at the e and g positions in NHR and the a and d positions in CHR. The sequences of N36, C34, T20, MPER, N63, MPER and Loop peptide are shown.