Schematic diagram illustrating the proposed signaling pathway involved in ATPγS-induced COX-2 expression and PGE2 generation in A549 cells.
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posted on 2013-02-19, 17:19 authored by Shin-Ei Cheng, I-Ta Lee, Chih-Chung Lin, Wan-Ling Wu, Li-Der Hsiao, Chuen-Mao YangATPγS activates the P2 receptor/PKC/NADPH oxidase pathway to enhance ROS generation, which in turn initiates the activation of Jak2 and STAT3, and ultimately induces COX-2-dependent PGE2 generation in A549 cells.
