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SPX has little effect on changes in the pancreatic islets in IL-10-deficient mice.

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posted on 19.02.2013, 17:54 by Koro Gotoh, Megumi Inoue, Kentaro Shiraishi, Takayuki Masaki, Seiichi Chiba, Kimihiko Mitsutomi, Takanobu Shimasaki, Hisae Ando, Kansuke Fujiwara, Isao Katsuragi, Tetsuya Kakuma, Masataka Seike, Toshiie Sakata, Hironobu Yoshimatsu

(A) Representative images of insulin staining (left), Mallory-Azan staining (middle), and α-SMA staining (right) in pancreas sections from each group. Scale bar = 100 µm. (B−F) Insulin-staining area in the pancreas (B), intra-islet fibrosis area (C) and intra-lobular fibrosis area (D), hydroxyproline content (E) and α-SMA-positive cells (F) in each group (n = 6). *P<0.05 vs. the Sham group (wild-type or IL-10KO mice), #P<0.05 vs. SPX mice (wild-type). Treatment groups: Sham, fed a HF diet, given serum albumin and sham-operated; SPX, fed a HF diet, given serum albumin, and splenectomized; SPX+IL-10, fed a HF diet, given recombinant mouse IL-10 and splenectomized. Wild-type, wild-type mice; IL-10KO, IL-10-deficient mice.

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