Role of ATP in cell-death induced inflammation in peritoneal cavity.

(A, B) The total neutrophil (A) and monocyte (B) numbers in the peritoneal cavity of WT C57BL/6 mice and P2X7 receptor –deficient mice 4 hours after i.p. injection of heat-shocked necrotic EL4 cells. (C, D) The total neutrophil (C) and monocyte (D) numbers in peritoneal cavity of WT C57BL/6 mice and P2X7 receptor –deficient mice 16 hours after i.p. injection of heat-shocked necrotic EL4 cells. The data are combined results of 5 experiments and represented as means ±SEM (n =  total number of mice from the multiple experiments for each group). NS, not significant versus WT groups. PBS groups, WT mice received i.p. PBS.