Results of the Morris water maze test.

A, comparisons of average latency in the oriented navigation trial (A1) and average time spent in the target quadrant in the probe trial (A2) after Aβ_1–42 injection. B, comparisons of average latency (B1) and average time spent in the target quadrant (B2) after Rg1 treatment. Control group, intrahippocampal injection of normal saline and intraperitoneal injection of normal saline; Untreated group, intrahippocampal injection of Aβ_1–42 and intraperitoneal injection of normal saline; Rg1+GW9662 group, intrahippocampal injection of Aβ_1–42 and intraperitoneal injection of Rg1 and GW9662; Rg1 group, intrahippocampal injection of Aβ_1–42 and intraperitoneal injection of Rg1. Bars represent mean±SEM. n = 10. +,vs. control group, P<0.05. *, vs. untreated group, P<0.05. #, vs. Rg1+GW9662 group, P<0.05.