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Restoration of HIC-1 expression by saRNA (dsHIC1-2998) in breast cancer cells.

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posted on 2014-01-28, 02:46 authored by Feng Zhao, Shengli Pan, Yan Gu, Shanyu Guo, Qiancheng Dai, Yingyan Yu, Wei Zhang

A. The binding sites of four saRNAs targeting the HIC-1 promoter. All the dsRNAs were separate from CpG islands in the HIC-1 promoter. B. In MCF-7 cells, HIC-1 mRNA levels were upregulated 6.52-fold by dsHIC1-2998 transfection, compared with mock transfection (P<0.01). In MDA-MB-231 cells, HIC-1 mRNA levels were 3.37-fold upregulated by dsHIC1-2998 compared with mock (P<0.01).

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    Computational biologygenomicsGenome expression analysismicroarraysimmunologyImmunologic techniquesImmunohistochemical analysisClinical immunologyDiagnostic medicineClinical laboratory sciencesObstetrics and gynecologybreast canceroncologyCancers and neoplasmsBreast tumorsBasic cancer researchhic-1sarnacancer

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