Fig_8.tif (2.93 MB)
Regulator effects network generated from Ingenuity Pathways Analysis.
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posted on 2015-07-22, 02:59 authored by Jingyi Gan, Hans-Joachim Sonntag, Mei kuen Tang, Dongqing Cai, Kenneth Ka Ho LeeUpstream regulators are displayed in the top tier, while diseases, functions and phenotypes are displayed in the bottom tier. The dataset genes that connect the upper regulators and the lower diseases and functions are displayed in the middle tier. The causal consistency relationships are represented with orange and blue lines, while the inconsistent relationships are represented as yellow line. Note that some of the dataset genes displayed in the middle tier may have been predicted to be activated or inhibited by upstream regulators, and under such situation is colored orange or blue, respectively (for example CCND1 and E2F1 in the network).
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bioinformatics analysisRegulator Effects network analysisgrowth arrestgene ontologyipaheart tissuesmicroarray analysisgene ontology categoriesgatatranscriptional regulationgene interaction networksPostnatal Mouse Heart TranscriptomeFunctional annotationcardiomyocyte exitIGF 1Rpostnatal heart developmentinfarcted heartmyhtaspdnamouse heartscardiomyocyte proliferationIngenuity Pathways Analysisinteraction networkstobaifIntegrative analysisenrichment analysespostnatal mouse heartsKEGG pathwaycell cycleTFF
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