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Random forest analysis of the plasma metabolome.
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posted on 2015-03-20, 04:01 authored by Satoshi Kume, Masanori Yamato, Yasuhisa Tamura, Guanghua Jin, Masayuki Nakano, Yukiharu Miyashige, Asami Eguchi, Yoshiyuki Ogata, Nobuhito Goda, Kazuhiro Iwai, Emi Yamano, Yasuyoshi Watanabe, Tomoyoshi Soga, Yosky KataokaThe mean decrease in accuracy from the random forest analysis was used to rank metabolites according to their prognostic importance for fatigue status. The 15 most important metabolites among three groups (control, food-restricted, and fatigued) or two groups (fatigued and a combined control and food-restricted group) are shown in A and B, respectively.
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Fatigue Identifiedurea cycle48 metabolitesfatigue loadingRat Modelweight reduction2.2 cmPlasma Metabolome Analysisfatigue pathophysiologycitrate cyclecomponent analysisplasma metabolomic analysisacid metabolismNitric oxideplasma metabolomeatpanimal group5 daysplasma levelsoxidative stressmultivariate analysesEnergy metabolismPotential Biomarkersproline metabolismplasma metabolites
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