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Protection of mice from lung viremia.
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posted on 2013-02-21, 02:32 authored by Otfried Kistner, Brian A. Crowe, Walter Wodal, Astrid Kerschbaum, Helga Savidis-Dacho, Nicolas Sabarth, Falko G. Falkner, Ines Mayerhofer, Wolfgang Mundt, Manfred Reiter, Leopold Grillberger, Christa Tauer, Michael Graninger, Alois Sachslehner, Michael Schwendinger, Peter Brühl, Thomas R. Kreil, Hartmut J. Ehrlich, P. Noel BarrettGroups of CD1 mice were immunized twice with five-fold serial dilutions of pandemic H1N1 (H1N1 A/California/7/2009) whole virus vaccine, before being challenged intranasally with 105 TCID50. Lungs were harvested at day three after challenge, and virus titers determined as described (Methods). Lack of detection of virus in lungs was considered indicative of protection.