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Pparg determines longevity.

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posted on 2009-12-04, 00:45 authored by Carmen Argmann, Radu Dobrin, Sami Heikkinen, Aurélie Auburtin, Laurent Pouilly, Terrie-Anne Cock, Hana Koutnikova, Jun Zhu, Eric E. Schadt, Johan Auwerx

(A) Lifespan of hypomorphic (hyp) Pparg deficient mice (n = 38 wild type and 24 Pparγhyp/hyp mice). ** p = 0.003. (B) Lifespan of Pparg2 knock-out mice (n = 25 wild type and 26 Pparg2−/− mice). * p = 0.020 when mice >120 weeks were excluded from the test.

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