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Post-exposure treatment of DOG4 RV-infected mice with metyrapone blocks the rise in corticosterone associated with pathogenic RABV.
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posted on 2014-04-24, 04:10 authored by Keith Schutsky, Carla Portocarrero, D. Craig Hooper, Bernhard Dietzschold, Milosz FaberMice were infected with 104 FFU of DOG4 RABV i.n. and either mock treated with PBS or treated with metyrapone (100 mg/kg) i.p. each day for 21 days. Ten mice per group were bled 1 hr after injection for each time point. The results represent comparative levels of corticosterone (+/− SE). *p<.05, **p<.01, and ***p<.001, respectively.
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BiochemistrymetabolismimmunologyClinical immunologyimmunomodulationimmunotherapyImmune suppressionimmunityImmunity to infectionsmicrobiologyVirologyViral transmission and infectionneurovirulenceEmerging viral diseasesViral immune evasionViral replicationViral vaccinesneuroscienceNeural homeostasissystems biologyVeterinary scienceVeterinary diseasesZoonosesrabiesInfectious diseasesViral diseasesPathology and laboratory medicinepathogensVirulence factorsdog4rv-infectedmicemetyraponeblockscorticosteronepathogenic
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