Figure_7.tif (432.94 kB)
Post-HTS triage.
figure
posted on 2013-11-18, 03:00 authored by Jayme L. Dahlin, Rondedrick Sinville, Jonathan Solberg, Hui Zhou, Junhong Han, Subhashree Francis, Jessica M. Strasser, Kristen John, Derek J. Hook, Michael A. Walters, Zhiguo Zhang(A) Post-HTS triage schematic. Italics = HTS library samples. (B) Summary of confirmatory dose-responses, as classified by shape. Full response: >95% percent inhibition span and two horizontal asymptotes; partial response: >30% span; marginal response: >15% span. (C) IC50 profile of purchased solid samples. (D) Chemical structures of representative artifact compounds identified by the orthogonal slot blot assay.
