Figure_4.tif (4.46 MB)
Phenotypic variability within the 129/Sv strain.
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posted on 2013-02-20, 22:06 authored by Bruno L. Lima, Enrico J. C. Santos, Gustavo R. Fernandes, Christian Merkel, Marco R. B. Mello, Juliana P. A. Gomes, Marina Soukoyan, Alexandre Kerkis, Silvia M. G. Massironi, José A. Visintin, Lygia V. Pereira(A) Comparison of histological slides and radiography of 129/Sv heterozygotes at 3 months of age show phenotypic variation in this strain. Wild-type (+/+), asymptomatic (AS) and severely affected (SE) heterozygous mice. (B) Average mean linear intercept at 3 and 6 months of age (*P<0.42, **P<0.0006, ***P<0.006). (C) Average thickness of thoracic aortic media at 3 and 6 months of age (*P<0.33, **P<0.04, †P<0.8, ††P<0.01). (D) Average KR at 3 and 6 months (*P<0.03, **P<0.04). (MI) Mildly affected animals. The number of animals analyzed in each group (n) and the ages (3 m and 6 m represent 3 months and 6 months, respectively) are shown.
