posted on 2013-02-21, 02:36authored byYoung-Beob Yu, Laura Dosanjh, Lixing Lao, Ming Tan, Bum Sang Shim, Yuan Luo
Age synchronized CL4176 worms were treated from egg until the L3 larval stage with CIN, GS (10 µg/ml) and SQDB (100 µg/ml). The animals were allowed to cultivate at 16°C for 38 h. At the 38 h time point, the temperature was up-shifted to 23°C. Worms began to paralyze 25 h after the temperature up-shift and were scored at 1 hr intervals. Data are expressed as percent (%) of worms not paralyzed. SQDB, GS and CIN alleviate β amyloid-induced toxicity in the transgenic C. elegans strain.