Fig_2.tif (2.02 MB)
PTP1B localizes to the mitochondria in COS-7 cells.
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posted on 2015-10-02, 03:16 authored by Julia Fueller, Mikhail V. Egorov, Kirstin A. Walther, Ola Sabet, Jana Mallah, Markus Grabenbauer, Ali KinkhabwalaConfocal images of COS-7 cells expressing mCitrine-PTP1B along with the mitochondrial marker Tom20-mTagBFP. The mCitrine-PTP1B chimera localized to the general ER (arrowhead) and at a higher local concentration to the mitochondria (arrow). Scale bar: 20 μm.
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PTP 1B tail anchorPTP 1B mitochondrial localizationtail anchorPTP 1B localizesendocytosed epidermal growth factor receptortransmembrane domain lengthMitochondria Depends SensitivelyPTP 1Bcanonical protein tyrosine phosphatase PTP 1BER insertion pathwaysPTP 1B insertionfluorescence lifetime imaging microscopyommdabprotein tyrosine phosphatase 1 Brat brain tissue
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