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Overexpression of miR-29a decreased GFAP, a marker of HSC, and increased expression in the acute response to injury and immunoreactivity in cholestasis.
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posted on 2015-08-25, 03:07 authored by Ying-Hsien Huang, Mao-Meng Tiao, Li-Tung Huang, Jiin-Haur Chuang, Kuang-Che Kuo, Ya-Ling Yang, Feng-Sheng WangThere was significantly higher expression of GFAP (green) in tissues from the BDL group than in tissues from the sham-operated group in WT mice. Moreover, miR-29a overexpression significantly downregulated GFAP protein expression in miR-29aTg mice with cholestasis compared with the WT littermates. Data are expressed as the mean ± SE of six samples per group. *indicates a p < 0.05 between the groups.
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HDAC 4Histone Deacetylases 4 BackgroundRecent studiesHDAC 4 functionprofibrogenic gene expressionhistone deacetylases 4migration assays.ResultsAfter BDLHSC migrationcholestatic liver fibrosisglial fibrillary acidic protein expressionprofibrogenic phenotypeantisense inhibitormirHSC activationHepatic Stellate CellsHSC proliferation.ConclusionsOur resultsActivated Hepatic Stellate Cells Modulates
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