Figure_5.tif (364.39 kB)
Other GPi-s also induce UCP2 expression in HepG2 cells.
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posted on 2013-07-25, 03:06 authored by Lilla Nagy, Tibor Docsa, Magdolna Szántó, Attila Brunyánszki, Csaba Hegedűs, Judit Márton, Bálint Kónya, László Virág, László Somsák, Pál Gergely, Péter Bai(A) Three GPi-s TH, NV50 and NV76 were tested on HepG2 cells. (B–C) HepG2 cells (n = 3) kept under normoglycemic conditions were treated with the inhibitors at the indicated concentrations for 8 hours, then (B) glycogen content and (C) UCP-2 expression was determined as described in Materials and Methods. Error is given as SD throughout the figure. * and *** indicate statistically significant difference between vehicle and GPi-treated groups at p<0.05, or p<0.001, respectively. VEH – vehicle, other abbreviations are in the text.
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BiochemistrymetabolismCarbohydrate metabolismMetabolic pathwaysdrug discoveryglycobiologyModel organismsAnimal modelsmouseMolecular cell biologyCellular stress responsesClinical research designAnimal models of diseaseDrugs and devicesDrug research and developmentEndocrinologyDiabetic endocrinologyDiabetes mellitus type 2gpi-sinduceucp2hepg2
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