Public Library of Science
Browse
Figure_1.tif (3 MB)

Optimal (A) and non-optimal (B) reaction activity in the reconstructed metabolic network of E. coli in glucose minimal medium (Materials and Methods).

Download (0 kB)
figure
posted on 2008-12-05, 01:14 authored by Takashi Nishikawa, Natali Gulbahce, Adilson E. Motter

The pie charts show the fractions of active and inactive reactions in the metabolic subsystems defined in the iJR904 database [75]. The color code is as follows: active reactions (red), inactive reactions due to mass balance (black) and environmental constraints (blue), inactive reactions due to the irreversibility (green) and cascading (yellow) mechanisms, and conditionally inactive reactions (orange), which are inactive reactions that can be active for other growth-maximizing states under the same medium condition. The optimal state shown in panel A was obtained by flux balance analysis (FBA, see Materials and Methods). The network is constructed by drawing an arrow from one subsystem to another when there are at least 4 metabolites that can be produced by reactions in the first subsystem and consumed by reactions in the second. Larger pies represent subsystems with more reactions.

History

Usage metrics

    PLOS Computational Biology

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC