Number of sequences in Pfam version 26 in comparison to the growth since version 25.

Upper line (red) indicates emerging new families not present in version 25, lower points (black) indicate a stable growth of the families in size. Not all data is shown. A. Region of up to 500 sequences, below the capabilities of most contact prediction methods. B. Region up to 40,000 sequences. Some families decrease their size (negative value on the ordinate axis), what might be attributed to redefinition of some families. Number of sequences range up to over 288,000 sequences (COX1 cytochrome c oxidase family), but with low density.