Figure_3.tif (3.37 MB)
Negative-stain electron microscopic (EM) image classificaion of the EBV gHgL/gp42/HLA-DQ2 triggering complex.
figure
posted on 2014-08-21, 03:33 authored by Karthik Sathiyamoorthy, Jiansen Jiang, Yao Xiong Hu, Cynthia L. Rowe, Britta S. Möhl, Jia Chen, Wei Jiang, Elizabeth D. Mellins, Richard Longnecker, Z. Hong Zhou, Theodore S. Jardetzky(A) A representative negative-stain EM image of gHgL/gp42/HLA-DQ2 sample. (B) Representative class averages of gHgL/gp42. Shown to the side is a schematic representation depicting the variability in the gp42 CTLD position along the length of gHgL before HLA-class II binding. (C) Representative class averages of gHgL/gp42/HLA-DQ2 complexes in open and closed conformations in ∼50∶50 proportion. The particle numbers included in the ternary complex classes are also indicated in each class average in (C).