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Negative-stain electron microscopic (EM) image classificaion of the EBV gHgL/gp42/HLA-DQ2 triggering complex.

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posted on 2014-08-21, 03:33 authored by Karthik Sathiyamoorthy, Jiansen Jiang, Yao Xiong Hu, Cynthia L. Rowe, Britta S. Möhl, Jia Chen, Wei Jiang, Elizabeth D. Mellins, Richard Longnecker, Z. Hong Zhou, Theodore S. Jardetzky

(A) A representative negative-stain EM image of gHgL/gp42/HLA-DQ2 sample. (B) Representative class averages of gHgL/gp42. Shown to the side is a schematic representation depicting the variability in the gp42 CTLD position along the length of gHgL before HLA-class II binding. (C) Representative class averages of gHgL/gp42/HLA-DQ2 complexes in open and closed conformations in ∼50∶50 proportion. The particle numbers included in the ternary complex classes are also indicated in each class average in (C).

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