NO-driven hypoxia and angiogenesis in BIA and CIA mice.

A. Serum NO and LA levels in BIA mice (n = 3); B. Serum NO and LA levels in CIA mice (n = 3); C. Immunohistochemical staining against HIF-1α in the articular synovium of CIA mice (×200); D. Immunohistochemical staining against VEGF in the articular synovium of CIA mice (×200). Sampling and detection were conducted after modeling for 3 d in CIA mice. The singular asterisk (*) represents statistically significant difference from the control (P<0.05); and double asterisks (**) indicate statistically very significant difference from the control (P<0.01).