Mpv17-/- mouse liver mitochondria have significantly reduced levels of two precursors of DNA synthesis, dGTP and dTTP.
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posted on 2016-01-18, 15:33 authored by Ilaria Dalla Rosa, Yolanda Cámara, Romina Durigon, Chloe F. Moss, Sara Vidoni, Gokhan Akman, Lilian Hunt, Mark A. Johnson, Sarah Grocott, Liya Wang, David R. Thorburn, Michio Hirano, Joanna Poulton, Robert W. Taylor, Greg Elgar, Ramon Martí, Peter Voshol, Ian J. Holt, Antonella SpinazzolaThe abundance of dNTPs was determined by means of an extension assay after extraction of nucleotides from liver (A), kidney (B) or brain (C) of Mpv17+/+ and Mpv17-/- mice (see Methods). All mice (n = 5) were sacrificed between 8 and 10 weeks of age. P values were obtained using Mann-Whitney test (* P<0.05, NS, not significant P>0.05).
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dNTP levelsMitochondria MPV 17mitochondrial DNA lossMPV 17 deficiencymitochondrial DNA depletiondysfunction causes mitochondrial DNA abnormalitiesMPV 17 Loss Causes Deoxynucleotide Insufficiencydeoxynucleoside supplementationSlow DNA Replicationmitochondrial deoxynucleotide homeostasismitochondrial genomic instabilityDNA copy numberMPV 17 disease models
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