Major mechanisms of chromosome missegregation.

Based on previous experimental data [6] mis-segregation was simulated as resulting from sister-chromatid non-disjunction resulting in one monosomic and one trisomic daughter cell (upper panel) and chromatid lagging resulting in monosomy in one daughter nucleus (lower panel). Each of these events was approximately equal in frequency, in all resulting in an average of 75% aneuploid daughter cells (red and green background) per mis-segregation event.